There are many genetic and environmental factors that play a role in women's health and fertility. These factors are intertwined genetic and environmental factors such as obesity, insulin resistance, folate metabolism, omega-3 fatty acids, gluten sensitivity and lactose intolerance. The factor that plays the most important role in women's health and fertility is estrogen metabolism. Estrogen enables the ovarian follicles to grow and mature and the uterus to become ready for pregnancy. Normal estrogen levels are critical for maintaining a regular, healthy menstrual cycle and successful pregnancy. However, hormonal imbalances or excessive increases or decreases in estrogen levels can lead to fertility problems or pregnancy problems.

Estrogen increases calcium absorption by bones and maintains bone mineral density. Therefore, low levels of estrogen can increase the risk of bone loss and osteoporosis. Estrogen has a protective effect against heart diseases. Estrogen levels also affect mental health and emotional state. Problems in estrogen metabolism may increase the risk of breast, ovarian and endometrial cancer in women.

A balanced and healthy diet is extremely important for women's health and fertility. Adequate vitamin, mineral and nutrient intake maintains hormonal balance and has positive effects on fertility. It is vital to know personal risks (insulin resistance, gluten sensitivity, lactose intolerance) and needs (folic acid, choline, omega-3) for adequate and balanced nutrition. Nutrigenetic-based epigenetic nutrition will help protect general women's health and will also positively affect female fertility.