Sleep is the basic element of a healthy life. A healthy sleep helps cell regeneration, tissue repair, strengthening the immune system and regulating metabolism. Quality sleep improves mental functions, ability to focus and cognitive performance. Insufficient sleep can increase the risk of high blood pressure, heart disease and stroke. A healthy and quality sleep can be achieved with the harmony of many genetic and environmental factors. Factors that determine sleep hygiene, such as a person's genetic chronotype, sensitivity to external stimuli, caffeine metabolism, and melatonin level, are genetically based. Harmonizing lifestyle with genetic predispositions increases sleep quality and benefits from sleep.